Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.42 |
| ▸ | PRKCI | P41743 | 9/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499579 | 0.82 | MAPK9 (0.39) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| SCHEMBL8498518 | 0.81 | PRKCI (0.51) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| SCHEMBL7210479 | 0.79 | ADORA1 (0.52) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| SCHEMBL7210499 | 0.79 | ADORA1 (0.52) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| SCHEMBL7210481 | 0.79 | ADORA1 (0.52) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| Hydrochloric Acid SCHEMBL7216474 | 0.78 | ADORA1 (0.51) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| Hydrochloric Acid SCHEMBL7216482 | 0.78 | ADORA1 (0.51) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| Hydrochloric Acid SCHEMBL7216480 | 0.78 | ADORA1 (0.51) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA | |
| SCHEMBL6936731 | 0.76 | NAMPT (0.44) | NAMPTMAPK13MAPK14MAPK12 | |
| SCHEMBL6935679 | 0.75 | PRKCI (0.51) | PRKCIMAPK9MAP4K4CSNK1DCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |