Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 6/20 | 0.46 |
| ▸ | AKT1 | P31749 | 6/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.44 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.44 |
| ▸ | FRK | P42685 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210479 | 1.00 | ADORA1 (0.52) | ADORA1ADORA2APRKCICDK2AKT1 | |
| SCHEMBL7210499 | 1.00 | ADORA1 (0.52) | ADORA1ADORA2APRKCICDK2AKT1 | |
| Hydrochloric Acid SCHEMBL7216474 | 0.99 | ADORA1 (0.51) | ADORA1ADORA2APRKCICDK2AKT1 | |
| Hydrochloric Acid SCHEMBL7216480 | 0.99 | ADORA1 (0.51) | ADORA1ADORA2APRKCICDK2AKT1 | |
| Hydrochloric Acid SCHEMBL7216482 | 0.99 | ADORA1 (0.51) | ADORA1ADORA2APRKCICDK2AKT1 | |
| Hydrochloric Acid SCHEMBL7235704 | 0.94 | ADORA1 (0.46) | ADORA1ADORA2APRKCICDK2AKT1 | |
| SCHEMBL7216686 | 0.88 | PRKCI (0.49) | ADORA1PRKCIPRKCDPRKCAPRKCH | |
| SCHEMBL7216693 | 0.88 | PRKCI (0.49) | ADORA1PRKCIPRKCDPRKCAPRKCH | |
| SCHEMBL7216689 | 0.88 | PRKCI (0.49) | ADORA1PRKCIPRKCDPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL7210186 | 0.87 | PRKCI (0.49) | ADORA1PRKCIPRKCDPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610698-B2 | Treatment of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and interleukin-8 mediated diseases | AMGEN, INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | AMGEN INC. | 2003-04-10 | — | — | US | disclosed |
| US-6410729-B1 | ANALGESICS; ANTIDIABETIC AGENTS; ANTIINFLAMMATORY AGENTS | AMGEN INC. | 2002-06-25 | — | — | US | disclosed |
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069425-A1 | Substituted pyrimidine compounds and methods of use | DPYD, IL6, IL1B | ADORA1 145/4885ADORA2A 188/4885PRKCI 3097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.