Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11777969 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL6379725 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL8500856 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL6680538 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL3625544 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL2112457 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL6683681 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL282602 | 0.95 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL445067 | 0.93 | ALDH1A1 (0.70) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Hydrochloric Acid SCHEMBL28408129 | 0.91 | ALDH1A1 (0.67) | ALDH1A1HPGDALOX15ALOX12CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952316-A | FOR TREATING AUTOIMMUNE DISEASES, E.G., RHEUMATIOD ARTHRITIS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-14 | — | — | US | disclosed |