Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27358257 | 0.76 | KDM4E (0.47) | KDM4ETSHRPOLBTDP1ALDH1A1 | |
| SCHEMBL4031586 | 0.76 | POLB (0.46) | KDM4ETSHRPOLBTDP1ALDH1A1 | |
| SCHEMBL8089248 | 0.76 | KDM4E (0.47) | KDM4ETSHRPOLBTDP1ALDH1A1 | |
| SCHEMBL17844038 | 0.76 | KDM4E (0.47) | KDM4ETSHRPOLBTDP1ALDH1A1 | |
| SCHEMBL27649665 | 0.75 | CYP3A4 (0.46) | POLBALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL8500994 | 0.74 | KDR (0.46) | KDR | |
| SCHEMBL5594263 | 0.73 | KDR (0.57) | KDM4ETSHRPOLBKDR | |
| SCHEMBL21753738 | 0.72 | KDM4E (0.44) | KDM4ETSHRPOLBTDP1ALDH1A1 | |
| SCHEMBL8500406 | 0.71 | RPS6KA5 (0.40) | KDM4E | |
| SCHEMBL28468058 | 0.71 | PTK2 (0.44) | KDM4ETSHRPOLBTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946559-A2 | IMIDAZOPYRIDAZINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028299-A2 | IMIDAZOPYRIDAZINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-07-02 | — | — | WO | disclosed |