SCHEMBL8499758

CC(=O)NC(c1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)C=C[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.57

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	AR	P10275	8/20	0.51

▸	SRD5A2	P31213	1/20	0.49

▸	KCNH2	Q12809	5/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8498314	0.85	SRD5A1 (0.49)	SRD5A2
SCHEMBL5217207	0.84	AR (0.58)	ARSRD5A2KCNH2
SCHEMBL8499485	0.83	AR (0.58)	ARSRD5A2KCNH2
SCHEMBL8500110	0.82	AR (0.57)	ARSRD5A2KCNH2
SCHEMBL8499203	0.79	AR (0.53)	ARSRD5A2KCNH2
SCHEMBL8499232	0.77	AR (0.51)	ARSRD5A2KCNH2
SCHEMBL8496146	0.77	AR (0.61)	ARSRD5A2KCNH2
SCHEMBL8498646	0.76	AR (0.54)	ARSRD5A2KCNH2
SCHEMBL8499496	0.76	AR (0.60)	ARSRD5A2KCNH2
SCHEMBL8498413	0.76	AR (0.60)	ARSRD5A2KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0649431-B1	17-AMINO SUBSTITUTED 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS	MERCK & CO INC (US)	1999-08-11	—	—	EP	claimed