SCHEMBL8500109

SCHEMBL8500109

O=C(O)c1cc2cc(F)ccc2[nH]c1=O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.63
ALDH1A1 P00352 2/20 0.63
DAO P14920 2/20 0.63
HPGD P15428 2/20 0.63
HSD17B10 Q99714 2/20 0.63
PDPK1 O15530 1/20 0.63
LMNA P02545 1/20 0.63
TSHR P16473 1/20 0.63
NFKB1 P19838 1/20 0.63
APEX1 P27695 1/20 0.63
CYP2C19 P33261 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
GAA P10253 2/20 0.61
POLB P06746 1/20 0.61
FLT3 P36888 4/20 0.49
DDO Q99489 1/20 0.46
KEAP1 Q14145 1/20 0.43
ATM Q13315 1/20 0.43
MLLT1 Q03111 1/20 0.43
HRH4 Q9H3N8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1368448 0.88 DAO (0.65) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL31423115 0.87 DAO (0.63) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL31422840 0.85 DAO (0.61) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL19126580 0.81 DAO (0.56) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL29415468 0.81 KDM4E (0.63) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL2806050 0.81 KDM4E (0.63) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL19145616 0.81 DAO (0.59) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL10969986 0.80 KDM4E (0.66) KDM4EALDH1A1DAOHPGDHSD17B10
SCHEMBL2310250 0.80 F7 (0.63) KDM4EALDH1A1DAOGAAPOLB
SCHEMBL2310539 0.80 KDM4E (0.61) KDM4EALDH1A1HPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5869661-A CONDENSING A 6-FLUOROQUINOLONECARBOXYLIC ACID WITH A SATURATED HETEROCYCLIC AMINE WITH OR WITHOUT A SOLVENT CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-02-09 US claimed
EP-0641782-A1 PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-03-08 EP claimed
JP-5294938-A None JP disclosed
EP-4705297-A1 SMALL MOLECULE THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-03-11 EP disclosed
WO-2024229205-A1 SMALL MOLECULE THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-11-07 WO disclosed
US-11939314-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2024-03-26 US disclosed
US-20230028687-A1 QUINOLIN-2-ONE DERIVATIVES MERCK PATENT GMBH (DE) 2023-01-26 US disclosed
US-20230028687-A1 QUINOLIN-2-ONE DERIVATIVES MERCK PATENT GMBH (DE) 2023-01-26 US disclosed
US-11186562-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-30 US disclosed
US-11186562-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-30 US disclosed
US-11174241-B2 Quinolin-2-one derivatives MERCK PATENT GMBH (DE) 2021-11-16 US disclosed
WO-2017121444-A1 QUINOLIN-2-ONE DERIVATIVES MERCK PATENT GMBH (DE) 2017-07-20 WO disclosed
US-5869661-A CONDENSING A 6-FLUOROQUINOLONECARBOXYLIC ACID WITH A SATURATED HETEROCYCLIC AMINE WITH OR WITHOUT A SOLVENT CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-02-09 US disclosed
US-5869661-A CONDENSING A 6-FLUOROQUINOLONECARBOXYLIC ACID WITH A SATURATED HETEROCYCLIC AMINE WITH OR WITHOUT A SOLVENT CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-02-09 US disclosed
EP-0641782-A1 PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-03-08 EP disclosed
EP-0641782-A1 PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-03-08 EP disclosed
EP-0641782-A4 PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE. CHUGAI PHARMACEUTICAL CO LTD (JP) 1994-10-17 EP disclosed
JP-H05294938-A PRODUCTION OF QUINOLONECARBOXYLIC ACID DERIVATIVE CHUGAI PHARMACEUT CO LTD 1993-11-09 JP disclosed
WO-1993002055-A1 PROCESS FOR PRODUCING QUINOLONECARBOXYLIC ACID DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1993-02-04 WO disclosed
US-5093529-A Process for the preparation of fluorinated benzoic acids CASSELLA AKTIENGESELLSCHAFT (DE) 1992-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11174241-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 KDM4E 460/4885ALDH1A1 2614/4885DAO 3826/4885
US-11939314-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 KDM4E 460/4885ALDH1A1 2614/4885DAO 3826/4885
US-20230028687-A1 QUINOLIN-2-ONE DERIVATIVES KIT, CDK2, CDK1 KDM4E 460/4885ALDH1A1 2614/4885DAO 3826/4885
US-11186562-B2 Quinolin-2-one derivatives KIT, CDK2, CDK1 KDM4E 460/4885ALDH1A1 2614/4885DAO 3826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.