Propylene Glycol

Propylene Glycol

SCHEMBL8500591

CC(O)CO.CCCCCCCCCCCCCCCC(O)C(O)(O)C(=O)O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 8/20 0.46
FFAR1 O14842 2/20 0.46
BLM P54132 2/20 0.43
HSPD1 P10809 1/20 0.43
HSPE1 P61604 1/20 0.43
FFAR4 Q5NUL3 1/20 0.42
ACE2 Q9BYF1 1/20 0.42
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
LCK P06239 1/20 0.41
PPARD Q03181 1/20 0.41
ZDHHC20 Q5W0Z9 1/20 0.41
ZDHHC2 Q9UIJ5 1/20 0.41
CYP2D6 P10635 2/20 0.40
SPHK1 Q9NYA1 1/20 0.40
GMNN O75496 1/20 0.40
POLB P06746 1/20 0.40
THPO P40225 1/20 0.40
MTOR P42345 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycerin SCHEMBL76901 0.92 GPR84 (0.49) GPR84FFAR1BLMHSPD1HSPE1
Glycerin SCHEMBL158648 0.92 GPR84 (0.49) GPR84FFAR1BLMHSPD1HSPE1
SCHEMBL7148025 0.91 GPR84 (0.53) GPR84FFAR1BLMHSPD1HSPE1
SCHEMBL18322324 0.91 GPR84 (0.53) GPR84FFAR1BLMHSPD1HSPE1
SCHEMBL9297272 0.91 GPR84 (0.53) GPR84FFAR1BLMHSPD1HSPE1
SCHEMBL325989 0.91 GPR84 (0.53) GPR84FFAR1BLMHSPD1HSPE1
Ethylene Glycol SCHEMBL26926887 0.90 GPR84 (0.48) GPR84FFAR1BLMHSPD1HSPE1
Ammonia Solution, Strong SCHEMBL10519337 0.90 GPR84 (0.52) GPR84FFAR1BLMHSPD1HSPE1
SCHEMBL6686309 0.90 GPR84 (0.52) GPR84FFAR1BLMHSPD1HSPE1
Glycerin SCHEMBL5344838 0.89 GPR84 (0.46) GPR84FFAR1BLMHSPD1HSPE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5992354-A Combustion of nanopartitioned fuel MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1999-11-30 US disclosed
WO-1997003279-A9 COMBUSTION OF NANOPARTITIONED FUEL 1997-03-06 WO disclosed
WO-1997003279-A1 COMBUSTION OF NANOPARTITIONED FUEL MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1997-01-30 WO disclosed