Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235003 | 0.81 | PTGS2 (0.51) | MAPK14MAPK10HTR7MAPK13MAPK12 | |
| SCHEMBL7215276 | 0.81 | MAPK14 (0.52) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL7216217 | 0.79 | MAPK14 (0.50) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL7238327 | 0.78 | MAPK14 (0.45) | MAPK14MAPK10MAPK9CSNK1DRIPK3 | |
| SCHEMBL7240785 | 0.78 | MAPK14 (0.50) | MAPK14MAPK10MAPK9CSNK1DRIPK3 | |
| SCHEMBL7216200 | 0.78 | MAPK14 (0.42) | SCN9AMAPK14MAPK10SRCBRAF | |
| SCHEMBL6641993 | 0.78 | MAPK14 (0.44) | SCN9AMAPK14MAPK10MAPK9CSNK1D | |
| SCHEMBL6644619 | 0.76 | MAPK14 (0.42) | SCN9AMAPK14MAPK10MAPK9CSNK1D | |
| SCHEMBL27522556 | 0.71 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL7211830 | 0.70 | MAPK14 (0.40) | MAPK14MAPK10SRCBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | claimed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | claimed |