Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210591 | 0.91 | PTGS2 (0.49) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7215116 | 0.89 | PTGS2 (0.58) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7210237 | 0.83 | MAPK13 (0.50) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7210277 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| Dimethylamine SCHEMBL7210227 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7210483 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7210513 | 0.80 | MAPK14 (0.47) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7210216 | 0.80 | PTGS2 (0.48) | PTGS2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8502066 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1MAPK13MAPK12MAPK11 | |
| SCHEMBL7215223 | 0.79 | PTGS2 (0.71) | PTGS2PTGS1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948497-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024782-A2 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |