Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2875595 | 0.98 | CA1 (0.55) | CA1CA2CA7CA9CA12 | |
| SCHEMBL10935641 | 0.95 | CA1 (0.52) | CA1CA2CA7CA9CA12 | |
| Fluoride Ion SCHEMBL28269841 | 0.93 | CA1 (0.50) | CA1CA2CA7CA9CA12 | |
| SCHEMBL27698172 | 0.90 | CA1 (0.46) | CA1CA2CA7CA9CA12 | |
| SCHEMBL2687596 | 0.90 | CA1 (0.46) | CA1CA2CA7CA9CA12 | |
| Sulfuric Acid SCHEMBL27905058 | 0.86 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| SCHEMBL11391039 | 0.86 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| Sulfuric Acid SCHEMBL27905057 | 0.86 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| SCHEMBL10878789 | 0.86 | CA1 (0.43) | CA1CA2CA7CA9CA12 | |
| Fluoride SCHEMBL28184117 | 0.85 | CA1 (0.41) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | claimed |
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5480791-A | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | disclosed |
| US-3983000-A | BONDED VIA AN O-DIANISIDINE RESIDUE | CORNING GLASS WORKS (US) | 1976-09-28 | — | — | US | disclosed |
| US-3930951-A | 4,4'-BI(2-METHOXYBENZENE DIAZONIUM CHLORIDE) | CORNING GLASS WORKS (US) | 1976-01-06 | — | — | US | disclosed |