SCHEMBL8501250

SCHEMBL8501250

COc1ccc(-c2ccccc2)c([N+]#N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 1/20 0.47
BACE1 P56817 2/20 0.47
CYP3A4 P08684 2/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2A6 P11509 2/20 0.47
CYP1A1 P04798 1/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2C8 P10632 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP4B1 P13584 1/20 0.47
CYP2B6 P20813 1/20 0.47
CYP3A5 P20815 1/20 0.47
CYP2A7 P20853 1/20 0.47
CYP3A7 P24462 1/20 0.47
CYP2F1 P24903 1/20 0.47
CYP2C18 P33260 1/20 0.47
CYP2C19 P33261 1/20 0.47
CYP2J2 P51589 1/20 0.47
CYP4F2 P78329 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8497285 0.98 PIN1 (0.46) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL28849676 0.89 SMN1; SMN2 (0.50) BACE1CYP3A4CYP1A2CYP2A6CYP1A1
SCHEMBL224709 0.79 GSTP1 (0.53) CYP3A4CYP1A2CYP2A6CYP1A1CYP2E1
SCHEMBL12325013 0.79 PTPN1 (0.57) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL5551697 0.79 PTPN1 (0.57) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL29402037 0.79 PTPN1 (0.57) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL25224874 0.78 CYP1A2 (0.50) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL5038147 0.78 BACE1 (0.42) PIN1BACE1CYP3A4CYP1A2CYP2A6
Hydrogen Sulfide SCHEMBL27936907 0.77 PTPN1 (0.56) PIN1BACE1CYP3A4CYP1A2CYP2A6
SCHEMBL7822185 0.76 ESR2 (0.55) PIN1BACE1CYP3A4CYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0599270-B1 Method of detecting phosphatase AISIN SEIKI (JP) 1999-05-12 EP claimed