Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12594358 | 0.87 | MAPT (0.40) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL14218374 | 0.84 | MAPT (0.50) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15215733 | 0.82 | L3MBTL1 (0.38) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8500377 | 0.81 | MAPT (0.39) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8500394 | 0.81 | MAPT (0.41) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15215734 | 0.79 | MAPT (0.38) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL5960188 | 0.77 | CA12 (0.49) | MAPTLMNAMEN1KMT2ASIRT5 | |
| SCHEMBL15038556 | 0.77 | MAPT (0.43) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15015577 | 0.76 | MAPT (0.35) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8499790 | 0.76 | MAPT (0.39) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757049-B1 | Camptothecin derivatives | TANABE SEIYAKU CO (JP) | 1999-03-24 | — | — | EP | disclosed |
| US-5837673-A | ANTITUMOR AGENTS AND ANTICARCINOGENIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-11-17 | — | — | US | disclosed |
| EP-0757049-A1 | Camptothecin derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |