Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502361 | 0.86 | ALDH1A1 (0.58) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL8501942 | 0.84 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL8499837 | 0.77 | PDGFRB (0.53) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL8499898 | 0.77 | PDGFRB (0.52) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL8562767 | 0.76 | PDGFRB (0.51) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL8563702 | 0.76 | PDGFRB (0.52) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL8502367 | 0.76 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL8504094 | 0.74 | SMN1; SMN2 (0.70) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL8503044 | 0.73 | MAPT (0.52) | MAPTSMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL3904447 | 0.73 | ALDH1A1 (0.58) | MAPTSMN1; SMN2ALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | claimed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | claimed |