Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 14/20 | 0.82 |
| ▸ | SLC2A1 | P11166 | 5/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.81 |
| ▸ | GMNN | O75496 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.81 |
| ▸ | HTR1A | P08908 | 1/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.81 |
| ▸ | HTR2A | P28223 | 1/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.81 |
| ▸ | SCN1A | P35498 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500508 | 0.93 | ADCY1 (0.82) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL9795878 | 0.92 | ADCY1 (0.80) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL10654969 | 0.92 | ADCY1 (0.79) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL10424475 | 0.91 | ADCY1 (0.79) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL8503348 | 0.91 | ADCY1 (0.79) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL10652381 | 0.90 | ADCY1 (0.78) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL10656020 | 0.90 | ADCY1 (0.80) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL9795994 | 0.90 | ADCY1 (0.78) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL8503517 | 0.90 | ADCY1 (0.87) | ADCY1SLC2A1MAPK1CYP3A4TSHR | |
| SCHEMBL8500754 | 0.90 | ADCY1 (0.82) | ADCY1SLC2A1MAPK1CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920146-A | GLAUCOMA AND CARDIAC FAILURE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-24 | — | — | US | claimed |
| US-5869520-A | REDUCING INTRAOCULAR PRESSURE | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5847167-A | Carbamoyloxlabdanes | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5646175-A | FOR TREATING CARDIAC FAILURE | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5543427-A | ADMINISTERING TO REDUCE INTRAOCULAR PRESSURE | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1996-08-06 | — | — | US | disclosed |
| US-5374650-A | Reducing intraocular pressure | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-4920146-A | GLAUCOMA AND CARDIAC FAILURE | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-24 | — | — | US | disclosed |
| EP-0294695-A2 | New polyoxygenated labdane derivatives, a process for their preparation, and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-12-14 | — | — | EP | disclosed |