SCHEMBL850218

SCHEMBL850218

Cc1cc(N2C(=O)CNC2=O)cc(C)c1CCS(=O)(=O)N1CCC2(CC1)N=C(c1cccc(OC(F)(F)F)c1)NC2=O

nearest known ligand 0.85

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTH1R Q03431 12/20 0.85
SCN9A Q15858 3/20 0.38
MMP2 P08253 1/20 0.33
MMP3 P08254 1/20 0.33
SLC6A9 P48067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL851533 0.91 PTH1R (0.71) PTH1RSCN9AMMP2MMP3SLC6A9
SCHEMBL18211210 0.85 PTH1R (0.65) PTH1RSCN9AMMP2MMP3SLC6A9
SCHEMBL16359085 0.85 PTH1R (0.62) PTH1RSCN9A
SCHEMBL850378 0.85 PTH1R (0.61) PTH1RSCN9A
SCHEMBL850379 0.85 PTH1R (0.61) PTH1RSCN9A
SCHEMBL850361 0.84 PTH1R (0.75) PTH1R
SCHEMBL848810 0.82 PTH1R (0.85) PTH1RSCN9AMMP2MMP3SLC6A9
SCHEMBL848836 0.81 PTH1R (0.57) PTH1RSCN9A
SCHEMBL848837 0.81 PTH1R (0.57) PTH1RSCN9A
SCHEMBL848082 0.81 PTH1R (0.60) PTH1RMMP2MMP3SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2433940-B9 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2015-10-28 EP claimed
US-9169254-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-27 US claimed
EP-2433940-B1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2014-09-24 EP claimed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US claimed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 EP claimed
US-20220162208-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-05-26 US disclosed
US-20210024524-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-01-28 US disclosed
US-9993462-B2 Hydantoin derivative-containing pharmaceutical composition CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-06-12 US disclosed
US-9993462-B2 Hydantoin derivative-containing pharmaceutical composition CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2018-06-12 US disclosed
US-20170112812-A1 HYDANTOIN DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2017-04-27 US disclosed
US-20170112812-A1 HYDANTOIN DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2017-04-27 US disclosed
US-20160326175-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2016-11-10 US disclosed
US-9169254-B2 Spiroimidazolone derivative CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-27 US disclosed
US-20150274727-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
US-20150274727-A1 HYDANTOIN DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2015-10-01 US disclosed
EP-2433940-B1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2014-09-24 EP disclosed
WO-2014092061-A1 HYDANTOIN DERIVATIVE 中外製薬株式会社 (JP) 2014-06-19 WO disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US disclosed
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2012-10-25 US disclosed
EP-2433940-A1 SPIROIMIDAZOLONE DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 2012-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270838-A1 SPIROIMIDAZOLONE DERIVATIVE WNK3, REN, SGK3 PTH1R 1869/4885SCN9A 553/4885MMP2 2725/4885
US-20170112812-A1 HYDANTOIN DERIVATIVE-CONTAINING PHARMACEUTICAL COMPOSITION H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, H1-0 PTH1R 376/4885SCN9A 2206/4885MMP2 495/4885
US-20210024524-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 PTH1R 2316/4885SCN9A 1454/4885MMP2 2480/4885
US-20160326175-A1 HYDANTOIN DERIVATIVE SLC10A1, UGT1A1, CYP2D6 PTH1R 4241/4885SCN9A 735/4885MMP2 1744/4885
US-20150274727-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 PTH1R 2316/4885SCN9A 1454/4885MMP2 2480/4885
US-20220162208-A1 HYDANTOIN DERIVATIVE HRH4, HRH3, H1-3 PTH1R 2316/4885SCN9A 1454/4885MMP2 2480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.