Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 20/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501670 | 0.90 | PDGFRB (0.69) | PDGFRBPDGFRA | |
| SCHEMBL8502380 | 0.88 | PDGFRB (0.72) | PDGFRBPDGFRA | |
| SCHEMBL8502270 | 0.87 | PDGFRB (0.69) | PDGFRBPDGFRA | |
| SCHEMBL8172493 | 0.84 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL31060782 | 0.83 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL8501632 | 0.81 | PDGFRB (0.65) | PDGFRBPDGFRA | |
| SCHEMBL2769498 | 0.80 | CFD (0.67) | — | |
| SCHEMBL31060975 | 0.79 | PDGFRB (1.00) | PDGFRBPDGFRA | |
| SCHEMBL8501509 | 0.79 | PDGFRB (0.97) | PDGFRBPDGFRA | |
| SCHEMBL4600656 | 0.78 | CFD (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE36256-E | ADMINISTERING ARYL-SUBSTITUTED QUINOXALINE DERIVATIVES AS ANTIPROLIFERATIVE, ANTICARCINOGENIC AND ANTITUMOR AGENTS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |