SCHEMBL850472

SCHEMBL850472

CS(=O)(=O)c1[nH]c2ccccc2c1CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CASP3 P42574 4/20 0.50
▸ MDM4 O15151 3/20 0.48
▸ TP53 P04637 3/20 0.48
▸ MDM2 Q00987 6/20 0.44
▸ SLC17A5 Q9NRA2 1/20 0.41
▸ TLR2 O60603 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30229718 0.89 MDM4 (0.51) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL27749256 0.89 MDM4 (0.51) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL30229529 0.89 MDM4 (0.51) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL850332 0.89 MDM4 (0.51) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL18795729 0.89 MDM4 (0.51) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL16100914 0.86 MDM4 (0.54) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL16100911 0.86 MDM4 (0.54) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL850327 0.84 MDM4 (0.42) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL377537 0.83 MDM4 (0.49) CASP3MDM4TP53MDM2SLC17A5
SCHEMBL24899350 0.83 MDM2 (0.47) CASP3MDM4TP53MDM2SLC17A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9109048-B2 Inhibition of tumor growth LYTIX BIOPHARMA AS (NO) 2015-08-18 — — US disclosed
US-8283315-B2 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2012-10-09 — — US disclosed
US-8143211-B2 Bioactive peptides LYTIX BIOPHARMA AS (NO) 2012-03-27 — — US disclosed
US-20080287346-A1 Bioactive peptides SVENDSEN JOHN SIGURD 2008-11-20 — — US disclosed
US-20080019993-A1 Inhibition of tumour growth LYTIX BIOPHARMA AS (NO) 2008-01-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287346-A1 Bioactive peptides VIP, NGLY1, IAPP CASP3 14/4885MDM4 425/4885TP53 42/4885
US-20080019993-A1 Inhibition of tumour growth STING1, VIP, MIF CASP3 147/4885MDM4 299/4885TP53 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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