Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.47 |
| ▸ | MDM4 | O15151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 3/20 | 0.44 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749256 | 0.94 | MDM4 (0.51) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL850332 | 0.94 | MDM4 (0.51) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL18795729 | 0.94 | MDM4 (0.51) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL30229718 | 0.94 | MDM4 (0.51) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL30229529 | 0.94 | MDM4 (0.51) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL16100914 | 0.84 | MDM4 (0.54) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL16100911 | 0.84 | MDM4 (0.54) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL31671078 | 0.83 | MDM4 (0.46) | MDM2MDM4TP53CASP3 | |
| SCHEMBL850472 | 0.83 | CASP3 (0.50) | MDM2MDM4TP53CASP3SLC17A5 | |
| SCHEMBL16100971 | 0.81 | MDM2 (0.49) | MDM2MDM4TP53CASP3SLC17A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192873-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023288213-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-01-19 | — | — | WO | disclosed |