Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | YWHAG | P61981 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476362 | 0.79 | CYP3A4 (0.60) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7092605 | 0.71 | CYP3A4 (0.56) | CA1CA2RAB9AMEN1KMT2A | |
| SCHEMBL8483573 | 0.70 | ERCC1 (0.59) | POLB | |
| SCHEMBL9750441 | 0.70 | CA12 (0.66) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10718079 | 0.68 | KDM4E (0.50) | CA1CA2MEN1KMT2ATRPA1 | |
| SCHEMBL10337295 | 0.68 | APP (0.62) | CA1CA2TRPA1YWHAGAPP | |
| SCHEMBL18607177 | 0.68 | TDP1 (0.58) | NPC1RAB9AKMT2AKDM4ELMNA | |
| SCHEMBL6841138 | 0.68 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL18735630 | 0.67 | KDM4E (0.53) | CA1CA2RAB9AMEN1KMT2A | |
| SCHEMBL9749965 | 0.67 | KMT2A (0.57) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1291345-B1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |