Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 8/20 | 0.59 |
| ▸ | ERCC4 | Q92889 | 8/20 | 0.59 |
| ▸ | USP4 | Q13107 | 1/20 | 0.54 |
| ▸ | USP7 | Q93009 | 1/20 | 0.54 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179001 | 0.79 | TDP1 (0.65) | POLB | |
| SCHEMBL107157 | 0.78 | ERCC1 (0.76) | ERCC1ERCC4HASPINALPGALPL | |
| SCHEMBL29190969 | 0.72 | USP4 (0.61) | USP4USP7HDAC3HDAC4HDAC1 | |
| SCHEMBL8269527 | 0.71 | KDM4E (0.69) | ERCC1ERCC4ALPGALPLTRPV1 | |
| SCHEMBL175299 | 0.70 | ERCC1 (0.66) | ERCC1ERCC4ALPGALPLTRPV1 | |
| SCHEMBL107288 | 0.70 | ERCC1 (0.66) | ERCC1ERCC4ALPGALPLTRPV1 | |
| SCHEMBL8506980 | 0.70 | CA12 (0.43) | POLB | |
| SCHEMBL17231376 | 0.70 | ALDH1A1 (0.60) | ERCC1ERCC4HASPINALPGHDAC1 | |
| SCHEMBL8507242 | 0.69 | ERCC1 (0.62) | ERCC1ERCC4ALPGALPLTRPV1 | |
| SCHEMBL8507183 | 0.69 | ERCC1 (0.62) | ERCC1ERCC4ALPGALPLTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1291345-B1 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |