Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508238 | 1.00 | PDE10A (0.49) | PDE10AAXLCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL8508526 | 0.86 | PDE10A (0.47) | PDE10AAXLCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL8507531 | 0.86 | PDE10A (0.47) | PDE10AAXLCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL8507524 | 0.84 | CHRNB4 (0.46) | PDE10ACHRNB4CHRNA3 | |
| SCHEMBL8507520 | 0.84 | CHRNB4 (0.46) | PDE10ACHRNB4CHRNA3 | |
| SCHEMBL8507536 | 0.82 | KDM4E (0.46) | AXLCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8508499 | 0.82 | KDM4E (0.46) | AXLCHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8509333 | 0.79 | LTA4H (0.47) | PDE10AAXLCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL8509351 | 0.79 | HPGD (0.53) | HRH3 | |
| SCHEMBL8508492 | 0.79 | HPGD (0.53) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923580-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997041120-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-11-06 | — | — | WO | disclosed |