Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510937 | 1.00 | KCNH2 (0.37) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8514028 | 0.96 | MEN1 (0.37) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8514032 | 0.96 | MEN1 (0.37) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8513967 | 0.93 | SIGMAR1 (0.41) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8513961 | 0.93 | SIGMAR1 (0.41) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8511081 | 0.92 | S1PR1 (0.42) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8512074 | 0.92 | MRGPRX1 (0.40) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8512069 | 0.92 | MRGPRX1 (0.40) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8511085 | 0.92 | S1PR1 (0.42) | KCNH2TMEM97SIGMAR1S1PR1MRGPRX1 | |
| SCHEMBL8514211 | 0.90 | S1PR1 (0.37) | KCNH2TMEM97SIGMAR1S1PR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309768-B2 | FTY720-derived anticancer agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120136063-A1 | FTY720-DERIVED ANTICANCER AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136063-A1 | FTY720-DERIVED ANTICANCER AGENTS | SPHK2, S1PR2, S1PR1 | KCNH2 2092/4885TMEM97 2265/4885SIGMAR1 1850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.