Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.54 |
| ▸ | RARA | P10276 | 4/20 | 0.54 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 5/20 | 0.43 |
| ▸ | PDE2A | O00408 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515775 | 0.86 | RARA (0.64) | RARBRARAAKT1RARGRXRA | |
| SCHEMBL8512225 | 0.80 | RARA (0.56) | RARBRARAAKT1RARG | |
| SCHEMBL17040898 | 0.73 | SSTR4 (0.47) | AKT1AKT2CNR1CNR2TACR3 | |
| SCHEMBL8515374 | 0.73 | RARB (0.60) | RARBRARAAKT1AKT2RARG | |
| SCHEMBL17109509 | 0.72 | AKT1 (0.43) | AKT1AKT2PDE2ACNR1CNR2 | |
| SCHEMBL14161397 | 0.72 | AKT1 (0.42) | AKT1AKT2PDE2ACNR1CNR2 | |
| Hydrochloric Acid SCHEMBL8612658 | 0.72 | RARA (0.58) | RARBRARAAKT1AKT2RARG | |
| Hydrochloric Acid SCHEMBL8514603 | 0.72 | RARA (0.58) | RARBRARAAKT1AKT2RARG | |
| SCHEMBL12633283 | 0.71 | AURKA (0.53) | RARBRARA | |
| SCHEMBL25156379 | 0.71 | AKT1 (0.51) | AKT1AKT2PDE2ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |