Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.61 |
| ▸ | TDO2 | P48775 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801758 | 0.82 | GRM2 (0.61) | GRM2TDO2ADORA3ADORA2AADORA2B | |
| SCHEMBL8511014 | 0.82 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL13726598 | 0.82 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL9604229 | 0.82 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL8510414 | 0.79 | GRM2 (0.67) | GRM2TDO2 | |
| SCHEMBL9896222 | 0.77 | GRM2 (0.63) | GRM2TDO2ADORA3ADORA2AADORA2B | |
| SCHEMBL8509657 | 0.77 | GRM2 (0.54) | GRM2 | |
| SCHEMBL8512917 | 0.77 | GRM2 (0.51) | GRM2 | |
| SCHEMBL21713352 | 0.77 | GRM2 (0.65) | GRM2TDO2 | |
| SCHEMBL8514311 | 0.75 | GRM2 (0.52) | GRM2TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785481-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885TDO2 1671/4885ADORA3 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.