Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.48 |
| ▸ | ACACB | O00763 | 5/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434155 | 0.86 | EGLN2 (0.48) | CYP11B2SCD5EIF2AK4JAK2JAK1 | |
| SCHEMBL485242 | 0.85 | CYP11B2 (0.51) | CYP11B2SCD5ACACBHIF1AEIF2AK4 | |
| SCHEMBL1432796 | 0.85 | POLB (0.53) | TSHRPOLBALDH1A1GPR119 | |
| SCHEMBL484102 | 0.84 | HIF1A (0.63) | CYP11B2HIF1ACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL20468942 | 0.83 | CYP3A4 (0.50) | CYP11B2SCD5ACACBHIF1ACYP2C9 | |
| SCHEMBL484886 | 0.82 | CYP11B2 (0.55) | CYP11B2SCD5HDAC2CYP2C9CYP3A4 | |
| SCHEMBL20468955 | 0.81 | CYP3A4 (0.51) | CYP11B2SCD5ACACBHIF1ACYP2C9 | |
| SCHEMBL20025395 | 0.81 | EIF2AK4 (0.44) | SCD5EIF2AK4JAK2JAK1POLB | |
| SCHEMBL8511358 | 0.80 | CYP11B2 (0.46) | CYP11B2SCD5ACACBHIF1AHDAC2 | |
| SCHEMBL30328547 | 0.80 | CYP11B2 (0.48) | CYP11B2SCD5ACACBHIF1AEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |