Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.60 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | EEF2K | O00418 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013525 | 0.85 | SLC1A3 (0.56) | SLC1A3SLC1A2SLC1A1EEF2KMAPT | |
| SCHEMBL10102615 | 0.82 | SLC1A3 (0.56) | SLC1A3SLC1A2SLC1A1HDAC8HDAC6 | |
| SCHEMBL2053891 | 0.82 | SLC1A3 (0.56) | SLC1A3SLC1A2SLC1A1HDAC8HDAC6 | |
| SCHEMBL15682748 | 0.81 | SERPINE1 (0.53) | SLC1A3SLC1A2SLC1A1HDAC8HDAC6 | |
| SCHEMBL15682743 | 0.81 | SERPINE1 (0.53) | SLC1A3SLC1A2SLC1A1HDAC8HDAC6 | |
| SCHEMBL1000596 | 0.79 | ALDH1A1 (0.62) | SLC1A3SLC1A2SLC1A1NPSR1MAPT | |
| SCHEMBL2161085 | 0.79 | ALDH1A1 (0.62) | SLC1A3SLC1A2SLC1A1NPSR1MAPT | |
| SCHEMBL2161104 | 0.79 | ALDH1A1 (0.62) | SLC1A3SLC1A2SLC1A1NPSR1MAPT | |
| SCHEMBL15387918 | 0.77 | ALDH1A1 (0.53) | SLC1A3SLC1A2SLC1A1EEF2KKMT2A | |
| SCHEMBL15387917 | 0.77 | ALDH1A1 (0.53) | SLC1A3SLC1A2SLC1A1EEF2KKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643295-A1 | GLYCINE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | Chiesi Farmaceutici S.p.A. (IT) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069275-A1 | GLYCINE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-05-31 | — | — | WO | disclosed |