Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.55 |
| ▸ | SKP1 | P63208 | 1/20 | 0.55 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.55 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273395 | 0.88 | CKS1B (0.55) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL18636766 | 0.88 | JAK3 (0.48) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL13472399 | 0.86 | CKS1B (0.56) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL17085624 | 0.86 | CKS1B (0.53) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL2277215 | 0.85 | CKS1B (0.53) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL21434039 | 0.84 | SMO (0.53) | CKS1BSKP1SKP2CNR1SMO | |
| SCHEMBL15446618 | 0.82 | CKS1B (0.54) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL8515361 | 0.82 | SMO (0.44) | CKS1BSKP1SKP2SMO | |
| SCHEMBL28381103 | 0.82 | CKS1B (0.56) | CKS1BSKP1SKP2SUV39H2CNR1 | |
| SCHEMBL23881624 | 0.81 | GPR119 (0.41) | CKS1BSKP1SKP2SUV39H2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |