Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509723 | 0.83 | GRM2 (0.53) | GRM2HTR2AHTR2CSLC6A4TDO2 | |
| SCHEMBL8512798 | 0.76 | GRM2 (0.49) | GRM2SLC6A4CYP2D6 | |
| SCHEMBL9604420 | 0.76 | GRM2 (0.57) | GRM2TDO2 | |
| SCHEMBL8514197 | 0.75 | GRM2 (0.48) | GRM2SLC6A4 | |
| SCHEMBL8513118 | 0.75 | GRM2 (0.40) | GRM2SLC6A4MAPK14BRD4 | |
| SCHEMBL8513414 | 0.73 | GRM2 (0.46) | GRM2TDO2 | |
| SCHEMBL8509698 | 0.73 | GRM2 (0.55) | GRM2HTR2CSLC6A4 | |
| SCHEMBL8511766 | 0.73 | GRM2 (0.54) | GRM2TDO2 | |
| SCHEMBL8513657 | 0.72 | GRM2 (0.53) | GRM2TDO2 | |
| SCHEMBL8511863 | 0.72 | GRM2 (0.50) | GRM2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2705024-B1 | Alkyne benzotriazole derivatives | MERCK SHARP & DOHME (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9139576-B2 | Aminomethyl biaryl benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-09-22 | — | — | US | disclosed |
| US-8975286-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785481-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8772276-B2 | Alkyne benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2014-03-27 | — | — | US | disclosed |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| EP-2705025-A1 | HYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2704574-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2705024-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2704573-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-06 | — | — | US | disclosed |
| WO-2012151139-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012151140-A1 | HYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012151138-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012151136-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-06-14 | — | — | US | disclosed |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885HTR2A 93/4885HTR2C 91/4885 |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885HTR2A 179/4885HTR2C 130/4885 |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885HTR2A 179/4885HTR2C 130/4885 |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRM3, GRIN2C | GRM2 1/4885HTR2A 80/4885HTR2C 76/4885 |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | GRM2 1/4885HTR2A 93/4885HTR2C 88/4885 |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | GRM2 1/4885HTR2A 125/4885HTR2C 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.