Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.57 |
| ▸ | TDO2 | P48775 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926811 | 0.82 | GRM2 (0.61) | GRM2TDO2KDM4E | |
| SCHEMBL9604229 | 0.82 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL8511766 | 0.82 | GRM2 (0.54) | GRM2TDO2 | |
| SCHEMBL9604350 | 0.79 | GRM2 (0.64) | GRM2TDO2L3MBTL1 | |
| SCHEMBL9605391 | 0.77 | GRM2 (0.51) | GRM2TDO2 | |
| SCHEMBL21713352 | 0.77 | GRM2 (0.65) | GRM2TDO2 | |
| SCHEMBL13726598 | 0.77 | GRM2 (0.61) | GRM2TDO2 | |
| SCHEMBL8512914 | 0.76 | GRM2 (0.50) | GRM2TDO2 | |
| SCHEMBL21713779 | 0.73 | GRM2 (0.50) | GRM2TDO2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL3474857 | 0.72 | GRM2 (0.55) | GRM2TDO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139576-B2 | Aminomethyl biaryl benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-09-22 | — | — | US | disclosed |
| US-8975286-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-03-10 | — | — | US | disclosed |
| US-8785482-B2 | Cyclohexene benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785481-B2 | Ether benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8772276-B2 | Alkyne benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-27 | — | — | US | disclosed |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. | 2014-03-27 | — | — | US | disclosed |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-06 | — | — | US | disclosed |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-06-14 | — | — | US | disclosed |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088150-A1 | CYCLOHEXENE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885TDO2 1280/4885ALDH1A1 3085/4885 |
| US-20120149677-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885TDO2 1671/4885ALDH1A1 3327/4885 |
| US-20120135977-A1 | ETHER BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRIK2 | GRM2 1/4885TDO2 1671/4885ALDH1A1 3327/4885 |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRM3, GRIN2C | GRM2 1/4885TDO2 1154/4885ALDH1A1 2342/4885 |
| US-20140088112-A1 | ALKYNE BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | GRM2 1/4885TDO2 1624/4885ALDH1A1 1808/4885 |
| US-20140088151-A1 | ALHYDROXYMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRIA2, GRM3 | GRM2 1/4885TDO2 1090/4885ALDH1A1 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.