SCHEMBL8513153

SCHEMBL8513153

CN1Cc2cc(C(=O)CNCc3nc4cc(F)c(F)cc4[nH]3)ccc2NC(CC(=O)O)C1=O

nearest known ligand 0.74

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 0.74
ITGAV P06756 20/20 0.74
ITGA2B P08514 4/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6946801 0.88 ITGB3 (0.75) ITGB3ITGAVITGA2B
SCHEMBL8516786 0.88 ITGB3 (0.75) ITGB3ITGAVITGA2B
SCHEMBL6946793 0.86 ITGB3 (0.60) ITGB3ITGAVITGA2B
SCHEMBL8329426 0.85 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL7367225 0.80 ITGB3 (0.76) ITGB3ITGAVITGA2B
SCHEMBL7333365 0.79 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL6941347 0.79 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL6947538 0.79 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL6947553 0.77 ITGB3 (0.77) ITGB3ITGAVITGA2B
SCHEMBL6677335 0.75 ITGB3 (0.68) ITGB3ITGAVITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977101-A Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity SMITHKLINE BEECHAM CORPORATION (US) 1999-11-02 US disclosed
US-5912180-A MIXING LIQUID SAMPLES WITH BORATE CAUSING LEAD TO PRECIPITATE, FILTERING PRECIPITATE FROM LIQUID, TESTING BY CONTACTING PRECIPITATE WITH REAGENT CAUSING COLORIMETRIC REACTION; FOR POLLUTION CONTROL HYBRIVET SYSTEMS, INC. (US) 1999-06-15 US disclosed
US-5416028-A Process for testing for substances in liquids HYBRIVET SYSTEMS, INC. (US) 1995-05-16 US disclosed