Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29604551 | 1.00 | PARP1 (0.46) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| Tert-Butyl Formate SCHEMBL28322954 | 0.84 | PARP1 (0.38) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL4076727 | 0.81 | PARP1 (0.46) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL13597596 | 0.78 | PARP1 (0.44) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL30313295 | 0.77 | CYP2C19 (0.46) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL24597088 | 0.75 | ATM (0.44) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL12115799 | 0.75 | PARP1 (0.41) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL28822882 | 0.74 | PARP1 (0.55) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL29865575 | 0.74 | PARP1 (0.55) | PARP1CYP2C19CDC7CDK2SLC22A12 | |
| SCHEMBL28337522 | 0.70 | CDC7 (0.48) | PARP1CYP2C19CDC7CDK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117892-B2 | Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION | 2021-09-14 | — | — | US | disclosed |
| US-20200207756-A1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2020-07-02 | — | — | US | disclosed |
| CN-110121499-A | (aza) indole-, benzothiophene-and benzofuran-3-sulfonamides | 优时比制药有限公司 | 2019-08-13 | — | — | CN | disclosed |
| CN-109942575-A | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-06-28 | — | — | CN | disclosed |
| CN-104926810-B | Pyrrolopyridine as kinase inhibitor | 阵列生物制药公司 | 2019-02-19 | — | — | CN | disclosed |
| EP-3268373-A1 | TRICYCLIC DLK INHIBITORS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2018-01-17 | — | — | EP | disclosed |
| CN-106715416-A | Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof | 辉瑞大药厂 | 2017-05-24 | — | — | CN | disclosed |
| WO-2016142310-A1 | TRICYCLIC DLK INHIBITORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| CN-104926810-A | Pyrrolopyridines As Kinase Inhibitors | ARRAY BIOPHARMA INC | 2015-09-23 | — | — | CN | disclosed |
| CN-102089307-B | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2015-07-01 | — | — | CN | disclosed |
| US-20120135999-A1 | COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT | PTC THERAPEUTICS, INC. (US) | 2012-05-31 | — | — | US | disclosed |
| CN-102089307-A | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2011-06-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135999-A1 | COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT | EIF2AK2, MAVS, ZC3HAV1 | PARP1 446/4885CYP2C19 4148/4885CDC7 1009/4885 |
| US-11117892-B2 | Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases | DYRK1A, DYRK2, DYRK1B | PARP1 1720/4885CYP2C19 3333/4885CDC7 526/4885 |
| US-20200207756-A1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | DYRK1A, DYRK2, DYRK4 | PARP1 1708/4885CYP2C19 3176/4885CDC7 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.