Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515307 | 0.93 | CKS1B (0.44) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8515036 | 0.88 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8514665 | 0.81 | CKS1B (0.48) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8510956 | 0.79 | CKS1B (0.47) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8513238 | 0.79 | CKS1B (0.47) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8514133 | 0.79 | CKS1B (0.48) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8510925 | 0.79 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL8513316 | 0.79 | CKS1B (0.45) | CKS1BSKP1SKP2MAP4K4SUV39H2 | |
| SCHEMBL3275117 | 0.78 | CKS1B (0.65) | CKS1BSKP1SKP2MAP4K4PRMT5 | |
| SCHEMBL8511684 | 0.78 | CKS1B (0.46) | CKS1BSKP1SKP2MAP4K4SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |