Dexbudesonide

SCHEMBL8513617

CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Dexbudesonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	10/20	0.75

▸	PGR	P06401	5/20	0.75

▸	CYP3A4	P08684	4/20	0.75

▸	HIF1A	Q16665	4/20	0.75

▸	SMN1; SMN2	Q16637	3/20	0.75

▸	LMNA	P02545	3/20	0.75

▸	CYP2C9	P11712	3/20	0.75

▸	NR3C2	P08235	2/20	0.75

▸	NFKB1	P19838	2/20	0.75

▸	THPO	P40225	2/20	0.75

▸	HSD17B10	Q99714	2/20	0.75

▸	BLM	P54132	2/20	0.75

▸	TSHR	P16473	2/20	0.75

▸	ABCC3	O15438	1/20	0.75

▸	ABCC4	O15439	1/20	0.75

▸	ABCB11	O95342	1/20	0.75

▸	IL5	P05113	1/20	0.75

▸	AR	P10275	1/20	0.75

▸	CHRM1	P11229	1/20	0.75

▸	MMP9	P14780	1/20	0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Dexbudesonide SCHEMBL8159866	0.89	NR3C1 (0.78)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL12396756	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Dexbudesonide SCHEMBL4095	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL13928654	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL1786635	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL13871728	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL14452945	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL13695912	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL21570019	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2
Budesonide SCHEMBL1130417	0.87	NR3C1 (1.00)	NR3C1PGRCYP3A4HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2034907-B1	EMBOLIC COILS AND RELATED COMPONENTS AND SYSTEMS	BOSTON SCIENT LTD (BB)	2012-05-30	—	—	EP	disclosed