Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | PTGFR | P43088 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514251 | 0.94 | PDE10A (0.44) | PDE10ATRPM8CTNNB1TCF7L2MAPT | |
| SCHEMBL8514932 | 0.91 | DHODH (0.49) | PDE10AMAPTDHODHPTGFRACP1 | |
| SCHEMBL8512120 | 0.90 | SCN9A (0.45) | PDE10ATRPM8CTNNB1TCF7L2MAPT | |
| SCHEMBL8512116 | 0.85 | PTGDR2 (0.37) | PDE10ATRPM8PTGFRPPARDPPARA | |
| SCHEMBL8514929 | 0.84 | DHODH (0.49) | PDE10AMAPTDHODHPTGFRACP1 | |
| SCHEMBL17593849 | 0.82 | PTGFR (0.56) | PDE10AMAPTDHODHPTGFRTSHR | |
| SCHEMBL18075813 | 0.80 | PDE10A (0.61) | PDE10AMAPTDHODHTSHR | |
| SCHEMBL8514758 | 0.78 | DHODH (0.44) | PDE10AMAPTDHODHPTGFRACP1 | |
| SCHEMBL8514061 | 0.78 | DHODH (0.42) | TRPM8DHODH | |
| SCHEMBL18987129 | 0.74 | POLB (0.50) | PDE10ADHODHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |