Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.72 |
| ▸ | PRKCI | P41743 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8513207 | 0.87 | PDE10A (0.55) | PDE10APRKCIMTOR | |
| SCHEMBL8514540 | 0.84 | PDE10A (1.00) | PDE10A | |
| SCHEMBL9610904 | 0.76 | PDE10A (0.59) | PDE10APRKCIMTOR | |
| SCHEMBL21758743 | 0.75 | GBA1 (0.55) | PDE10APRKCI | |
| SCHEMBL29915591 | 0.75 | GBA1 (0.55) | PDE10APRKCI | |
| SCHEMBL8513166 | 0.75 | PDE10A (1.00) | PDE10A | |
| SCHEMBL8514507 | 0.75 | PDE10A (0.57) | PDE10A | |
| SCHEMBL8514276 | 0.74 | PDE10A (0.79) | PDE10A | |
| SCHEMBL21753164 | 0.73 | MAPT (0.44) | PDE10APRKCIMTOR | |
| SCHEMBL21758445 | 0.73 | PDE10A (0.42) | PDE10APRKCIMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467382-B1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2467382-B1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8691827-B2 | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-04-08 | — | — | US | disclosed |
| US-8691827-B2 | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-04-08 | — | — | US | disclosed |
| EP-2467382-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | PDE12, PDE4A, PDE10A | PDE10A 3/4885PRKCI 2300/4885MTOR 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.