Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8514501 | 0.87 | PDE10A (0.72) | PDE10APRKCIMTOR | |
| SCHEMBL8587920 | 0.82 | PDE10A (0.76) | PDE10A | |
| SCHEMBL15440653 | 0.82 | ACHE (0.49) | PDE10AMAPTPRKCIMTOR | |
| SCHEMBL21753160 | 0.82 | PARP1 (0.42) | PDE10APRKCIMTOR | |
| SCHEMBL29915677 | 0.81 | MAPT (0.44) | MAPT | |
| SCHEMBL21753162 | 0.81 | MAPT (0.44) | MAPT | |
| SCHEMBL29915620 | 0.81 | MAPT (0.44) | MAPT | |
| SCHEMBL31246456 | 0.77 | MAPT (0.42) | PDE10AMAPTPRKCIMTOR | |
| SCHEMBL18303742 | 0.77 | ESR2 (0.45) | MTOR | |
| SCHEMBL21758756 | 0.76 | PARP1 (0.49) | PRKCIMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467382-B1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-2467382-B1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME (US) | 2014-06-25 | — | — | EP | disclosed |
| US-8691827-B2 | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-04-08 | — | — | US | disclosed |
| US-8691827-B2 | Amino tetrahydro-pyridopyrimidine PDE10 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-04-08 | — | — | US | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136012-A1 | AMINO TETRAHYDRO-PYRIDOPYRIMIDINE PDE10 INHIBITORS | PDE12, PDE4A, PDE10A | PDE10A 3/4885MAPT 1101/4885PRKCI 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.