Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14818738 | 0.98 | TSHR (0.71) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL19375077 | 0.94 | TSHR (0.66) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8903216 | 0.94 | TSHR (0.66) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8767072 | 0.93 | TSHR (0.63) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5369302 | 0.90 | CYP3A4 (0.59) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20862341 | 0.84 | CYP3A4 (0.53) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3632958 | 0.84 | TSHR (0.52) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL12656055 | 0.84 | CYP3A4 (0.52) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5352749 | 0.82 | ALDH1A1 (0.67) | TSHRCYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1911955 | 0.82 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ASMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043439-A1 | COMPOUNDS AS C5AR INHIBITORS | KIRA PHARMACEUTICALS (SUZHOU) LTD. (CN) | 2024-02-08 | — | — | US | disclosed |
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043439-A1 | COMPOUNDS AS C5AR INHIBITORS | C5AR1, C5AR2, C3AR1 | TSHR 565/4885CYP3A4 1730/4885CYP2C9 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.