Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20514255 | 0.87 | KMT2A (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL5190964 | 0.85 | KMT2A (0.61) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL31379781 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL31379772 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL31379778 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL31379779 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL31379777 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL10520278 | 0.83 | CTSD (0.56) | MAPTKMT2AMEN1NPSR1CTSD | |
| SCHEMBL6634673 | 0.83 | HDAC3 (0.63) | MAPTKMT2AMEN1NPSR1CTSD | |
| SCHEMBL8834120 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |