Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515513 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL9298448 | 0.90 | GAA (0.51) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL2549625 | 0.90 | GAA (0.51) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL3858960 | 0.90 | GAA (0.51) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL8535569 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL8535567 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL28561885 | 0.82 | CYP19A1 (0.54) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 | |
| SCHEMBL9390308 | 0.79 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL9390312 | 0.79 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL8996036 | 0.79 | RAB9A (0.55) | SMN1; SMN2ALDH1A1RAB9AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |