Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL752321 | 1.00 | MAPT (0.47) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL30733247 | 1.00 | MAPT (0.47) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL30238589 | 1.00 | MAPT (0.47) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL27698274 | 0.96 | MAPT (0.44) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL19859279 | 0.96 | MAPT (0.44) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL11800024 | 0.92 | MAPT (0.47) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL27668841 | 0.92 | MAPT (0.47) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL28990089 | 0.90 | MAPT (0.40) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL29234087 | 0.89 | MAPT (0.44) | MAPTALDH1A1TSHRCYP1A2HPGD | |
| Trolamine SCHEMBL721955 | 0.88 | MAPT (0.50) | MAPTALDH1A1TSHRCYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642973-A1 | COSMETIC COMPOSITION FOR SKIN WHITENING COMPRISING RESVERATROL | DSM IP Assets B.V. (NL) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012069362-A1 | COSMETIC COMPOSITION FOR SKIN WHITENING COMPRISING RESVERATROL | DSM IP ASSETS B.V. (NL) | 2012-05-31 | — | — | WO | disclosed |