SCHEMBL8515629

SCHEMBL8515629

CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8515630 1.00 BDKRB2 (1.00) BDKRB2
SCHEMBL8367755 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL8367753 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL8367386 0.92 BDKRB2 (0.84) BDKRB2
SCHEMBL8367385 0.92 BDKRB2 (0.84) BDKRB2
SCHEMBL6640858 0.91 BDKRB2 (1.00) BDKRB2
SCHEMBL6640854 0.91 BDKRB2 (1.00) BDKRB2
SCHEMBL8367971 0.91 BDKRB2 (1.00) BDKRB2
SCHEMBL8367967 0.91 BDKRB2 (1.00) BDKRB2
SCHEMBL8367819 0.90 BDKRB2 (0.82) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed