Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364206 | 0.94 | EGFR (0.51) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8366024 | 0.89 | EGFR (0.59) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8365488 | 0.87 | EGFR (0.56) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8367972 | 0.87 | EGFR (0.54) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8367307 | 0.87 | EGFR (0.52) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8367451 | 0.86 | EGFR (0.52) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8367547 | 0.85 | ERBB2 (0.52) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8368186 | 0.85 | EGFR (0.52) | EGFRERBB2ERBB4AURKBCHEK2 | |
| SCHEMBL8367388 | 0.85 | EGFR (0.53) | EGFRERBB2ERBB4JAK3MAPK13 | |
| SCHEMBL8367513 | 0.85 | EGFR (0.51) | EGFRERBB2ERBB4AURKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |