Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8367919 | 0.95 | EGFR (0.54) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL8367387 | 0.89 | EGFR (0.50) | EGFRERBB2SRC | |
| SCHEMBL8368308 | 0.87 | EGFR (0.49) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL8365522 | 0.85 | EGFR (0.47) | EGFRERBB2ERBB4JAK3SRC | |
| SCHEMBL8515724 | 0.85 | EGFR (0.52) | EGFRERBB2ERBB4JAK3MAP3K8 | |
| SCHEMBL8545642 | 0.85 | EGFR (0.47) | EGFRERBB2ERBB4JAK3SRC | |
| SCHEMBL8363483 | 0.85 | EGFR (0.49) | EGFRERBB2ERBB4JAK3 | |
| SCHEMBL8367792 | 0.84 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL8367320 | 0.83 | EGFR (0.54) | EGFRERBB2 | |
| SCHEMBL8516124 | 0.82 | EGFR (0.49) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035132-A1 | HETEROCYCLIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |