Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 18/20 | 0.76 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.76 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.76 |
| ▸ | CDK1 | P06493 | 2/20 | 0.76 |
| ▸ | CDK4 | P11802 | 2/20 | 0.76 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.76 |
| ▸ | CCND1 | P24385 | 2/20 | 0.76 |
| ▸ | ABL2 | P42684 | 2/20 | 0.76 |
| ▸ | GSK3A | P49840 | 2/20 | 0.76 |
| ▸ | CDK7 | P50613 | 2/20 | 0.76 |
| ▸ | CCNH | P51946 | 2/20 | 0.76 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.76 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17022949 | 0.92 | CDK9 (0.63) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8515811 | 0.89 | CDK9 (0.80) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL2024692 | 0.88 | CDK9 (0.66) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4117403 | 0.88 | CDK9 (0.65) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4426403 | 0.88 | CCNT1 (0.68) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4109219 | 0.87 | CDK9 (0.77) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL8516178 | 0.86 | CDK9 (0.79) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4108268 | 0.85 | CCNT1 (0.67) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4438340 | 0.84 | CCNT1 (0.66) | CDK9CCNT1MAP4K4CDK1CDK4 | |
| SCHEMBL4098058 | 0.84 | CCNT1 (0.74) | CDK9CCNT1MAP4K4CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137166-B1 | 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2012-05-30 | — | — | EP | claimed |