Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742157 | 0.82 | GPR119 (0.33) | GPR119 | |
| SCHEMBL1134280 | 0.79 | GPR119 (0.33) | GPR119 | |
| SCHEMBL1968451 | 0.78 | GPR119 (0.31) | GPR119 | |
| SCHEMBL87245 | 0.78 | POLB (0.42) | GPR119LMNAMAPK1 | |
| SCHEMBL4679698 | 0.78 | GPR119 (0.31) | GPR119 | |
| SCHEMBL25346880 | 0.78 | GPR119 (0.31) | GPR119 | |
| SCHEMBL51112 | 0.78 | GPR119 (0.34) | GPR119LMNAMAPK1 | |
| SCHEMBL442550 | 0.78 | CYP3A4 (0.44) | GPR119LMNA | |
| SCHEMBL52393 | 0.78 | GPR119 (0.31) | GPR119 | |
| SCHEMBL12162163 | 0.78 | GPR119 (0.30) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891002-B1 | CYCLOHEXANESULFONYL DERIVATIVES AS GLYT1 INHIBITORS TO TREAT SCHIZOPHRENIA | MERCK SHARP & DOHME (GB) | 2012-05-30 | — | — | EP | disclosed |