Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EDNRB | P24530 | 3/20 | 0.35 |
| ▸ | EDNRA | P25101 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7661976 | 0.90 | TP53 (0.42) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7663830 | 0.89 | TP53 (0.45) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL8516589 | 0.88 | CNR2 (0.41) | CNR2 | |
| Acetic Acid SCHEMBL8516329 | 0.88 | TP53 (0.41) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7660546 | 0.88 | TP53 (0.43) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7846340 | 0.88 | TP53 (0.39) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL8516991 | 0.87 | CAMK2D (0.38) | TP53CNR2 | |
| Acetic Acid SCHEMBL7657155 | 0.86 | TP53 (0.41) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7665406 | 0.85 | TP53 (0.41) | TP53RXFP1POLBMAPTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7663850 | 0.84 | TP53 (0.40) | TP53RXFP1POLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999046260-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |