SCHEMBL8516464

SCHEMBL8516464

CC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c(N(C)C)cc(C)nc34)c2Cl)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8516462 1.00 BDKRB2 (1.00) BDKRB2
SCHEMBL8367525 0.93 BDKRB2 (0.87) BDKRB2
SCHEMBL8516488 0.93 BDKRB2 (0.87) BDKRB2
SCHEMBL8367524 0.93 BDKRB2 (0.87) BDKRB2
SCHEMBL8516487 0.93 BDKRB2 (0.87) BDKRB2
SCHEMBL8365938 0.91 BDKRB2 (0.85) BDKRB2
SCHEMBL8365941 0.91 BDKRB2 (0.85) BDKRB2
SCHEMBL8365959 0.91 BDKRB2 (0.84) BDKRB2
SCHEMBL8366142 0.91 BDKRB2 (0.84) BDKRB2
SCHEMBL8366145 0.91 BDKRB2 (0.84) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994368-A ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, ANALGESICS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-11-30 US disclosed
EP-0807105-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-19 EP disclosed
WO-1996013485-A1 PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-05-09 WO disclosed