Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481520 | 0.88 | USP1 (0.47) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481506 | 0.88 | USP1 (0.47) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481507 | 0.88 | USP1 (0.47) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL2360028 | 0.81 | MTOR (0.44) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL2360032 | 0.81 | MTOR (0.44) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481112 | 0.81 | MTOR (0.44) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481751 | 0.80 | FYN (0.43) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481278 | 0.80 | FYN (0.43) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL481277 | 0.80 | FYN (0.43) | USP1FYNMTORFTOKDM5B | |
| SCHEMBL18726153 | 0.80 | MTOR (0.45) | USP1FYNMTORFTOKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457913-A2 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | Signal Pharmaceuticals LLC (US) | 2012-05-30 | — | — | EP | disclosed |