SCHEMBL8516577

SCHEMBL8516577

CS(=O)(=O)Nc1cccc(Nc2cc(-c3ccccc3)ncn2)c1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 7/20 0.86
CYP3A4 P08684 7/20 0.86
CYP2C19 P33261 5/20 0.86
CLK4 Q9HAZ1 4/20 0.86
CYP2C9 P11712 4/20 0.86
CYP2D6 P10635 3/20 0.86
TSHR P16473 2/20 0.86
USP2 O75604 2/20 0.86
BACE1 P56817 6/20 0.72
CCNT1 O60563 3/20 0.68
CDK9 P50750 3/20 0.68
MAP4K4 O95819 1/20 0.68
CDK1 P06493 1/20 0.68
CDK4 P11802 1/20 0.68
CCNB1 P14635 1/20 0.68
CCND1 P24385 1/20 0.68
ABL2 P42684 1/20 0.68
GSK3A P49840 1/20 0.68
CDK7 P50613 1/20 0.68
CCNH P51946 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8516573 0.89 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8513621 0.88 CYP1A2 (0.74) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL4109231 0.88 CCNT1 (0.77) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8515489 0.87 CCNT1 (0.68) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8516321 0.85 CYP1A2 (0.70) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8515866 0.85 CYP3A4 (0.70) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8515965 0.85 CYP1A2 (0.70) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL8514144 0.84 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL4109321 0.84 BACE1 (1.00) CYP1A2CYP3A4CYP2C19CLK4CYP2C9
SCHEMBL10193682 0.83 CYP1A2 (0.68) CYP1A2CYP3A4CYP2C19CLK4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137166-B1 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES INGENIUM PHARMACEUTICALS GMBH (DE) 2012-05-30 EP claimed