Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365842 | 0.85 | TSHR (0.47) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL17940345 | 0.83 | TSHR (0.46) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL11336480 | 0.80 | TSHR (0.75) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL1355502 | 0.80 | CA9 (0.46) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL27346903 | 0.79 | KDM4E (0.45) | TSHRSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL14086406 | 0.79 | CA2 (0.68) | TSHRKDM4EALDH1A1HSD17B10CA9 | |
| SCHEMBL1498169 | 0.78 | KDM4E (0.50) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10499129 | 0.78 | KDM4E (0.50) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27271173 | 0.78 | KDM4E (0.50) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL353392 | 0.78 | CA1 (0.63) | TSHRKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817630-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0817630-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |